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A total of three % of Lively material is excreted in urine as unchanged Lively material. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (2 %) by CYP2D6, which happen to be further more metabolised by conjugation. Therefore, active substance metabolism mediated by cytoch